Expression of HMMR in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hyaluronan-mediated motility receptor (RHAMM)

Protein class

CD markers, FDA approved drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040025	CAB002433

GENE INFORMATION
Gene name	HMMR (HGNC Symbol)
Synonyms	CD168, RHAMM
Description	Hyaluronan-mediated motility receptor (RHAMM) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
Chromosome	5
Cytoband	q34
Chromosome location (bp)	163460203 - 163491945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072571 (version 83.38)
Entrez gene	3161
UniProt	O75330 (UniProt - Evidence at protein level)
neXtProt	NX_O75330
Antibodypedia	HMMR antibodies

PROTEIN BROWSER

HMMR-001	HMMR-002	HMMR-003	HMMR-006	HMMR-007	HMMR-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMMR-001 ENSP00000377492 ENST00000393915	O75330 [Direct mapping] Hyaluronan mediated motility receptor Show all	CD markers Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0044281 [small molecule metabolic process] Show all	725 aa 84.2 kDa	No	0
HMMR-002 ENSP00000351554 ENST00000358715	O75330 [Direct mapping] Hyaluronan mediated motility receptor Show all	CD markers Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0044281 [small molecule metabolic process] Show all	724 aa 84.1 kDa	No	0
HMMR-003 ENSP00000185942 ENST00000353866	O75330 [Direct mapping] Hyaluronan mediated motility receptor Show all	CD markers Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0044281 [small molecule metabolic process] Show all	709 aa 82.3 kDa	No	0
HMMR-006 ENSP00000402673 ENST00000432118	O75330 [Direct mapping] Hyaluronan mediated motility receptor Show all	CD markers Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0044281 [small molecule metabolic process] Show all	638 aa 74.5 kDa	No	0
HMMR-007 ENSP00000428481 ENST00000520345	E5RI30 [Direct mapping] Hyaluronan mediated motility receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005540 [hyaluronic acid binding] Show all	102 aa 11.7 kDa	No	0
HMMR-008 ENSP00000428406 ENST00000522094	E5RIH2 [Direct mapping] Hyaluronan mediated motility receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005540 [hyaluronic acid binding] Show all	92 aa 10.7 kDa	No	0