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HMMR

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GENERAL INFORMATION

Gene name

 HMMR

Gene description

 Hyaluronan-mediated motility receptor (RHAMM)

Protein class

 CD markers
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubules. In addition localized to the cytosol & centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (validated)

Additional location

 In addition localized to the Centrosome (validated), Cytosol (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

Mouse

 Localized to the Nucleoli, Microtubules, Mitotic spindle, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB002433 , HPA043926 , HPA061524
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All non detected compartments HMMR detected in Microtubules, Centrosome and Cytosol

ASSAYS
RNA expression
Human cells
Custom data
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubules. In addition localized to the cytosol & centrosome.

Main location

 Microtubules (validated)

Additional location

 Centrosome (validated), Cytosol (validated)
CAB002433: A-431 1

CAB002433: A-431

 CAB002433: U-2 OS 2

CAB002433: U-2 OS

 CAB002433: U-251 MG 3

CAB002433: U-251 MG
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB002433 A-431 Cytosol
CAB002433 U-2 OS Microtubules
CAB002433 U-251 MG Microtubules
HPA043926 MCF7 Microtubules Intensity
HPA043926 U-2 OS Microtubules
Centrosome
HPA061524 RH-30 Microtubules Intensity
Cytosol
HPA061524 SiHa Microtubules Intensity
HPA061524 U-2 OS Cytosol

CUSTOM DATA
HPA043926: U-2 OS 1

HPA043926: U-2 OS

 HPA043926: U-2 OS 2

HPA043926: U-2 OS

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA043926 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. HMMR is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Microtubules

MOUSE CELLS

Main location

 Nucleoli, Microtubules, Mitotic spindle, Cytosol

Mouse gene

 ENSMUSG00000020330 (version 83)
HPA043926: NIH 3T3 1

HPA043926: NIH 3T3

 HPA043926: NIH 3T3 2

HPA043926: NIH 3T3

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA043926 NIH 3T3 Nucleoli
Microtubules
Mitotic spindle
Cytosol

GENE INFORMATION

Gene name

 HMMR (HGNC Symbol)

Synonyms

 CD168, RHAMM

Description

 Hyaluronan-mediated motility receptor (RHAMM) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 5

Cytoband

 q34

Chromosome location (bp)

 163460203 - 163491945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072571 (version 83.38)

Entrez gene

 3161

UniProt

 O75330 (UniProt - Evidence at protein level)

neXtProt

 NX_O75330

Antibodypedia

 HMMR antibodies

PROTEIN BROWSER
HMMR-001
HMMR-002
HMMR-003
HMMR-006
HMMR-007
HMMR-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMMR-001
ENSP00000377492
ENST00000393915
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 725 aa
84.2 kDa 		No 0
HMMR-002
ENSP00000351554
ENST00000358715
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 724 aa
84.1 kDa 		No 0
HMMR-003
ENSP00000185942
ENST00000353866
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 709 aa
82.3 kDa 		No 0
HMMR-006
ENSP00000402673
ENST00000432118
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 638 aa
74.5 kDa 		No 0
HMMR-007
ENSP00000428481
ENST00000520345
E5RI30 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
Show all
 102 aa
11.7 kDa 		No 0
HMMR-008
ENSP00000428406
ENST00000522094
E5RIH2 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
Show all
 92 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.