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The majority of colorectal cancers along with several hepatocellular carcinomas, testicular seminomas, urothelial, gastric and pancreatic cancers displayed weak to moderate cytoplasmic immunoreactivity. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
PANX2 (HGNC Symbol)
Synonyms
hPANX2, PX2
Description
Pannexin 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
