Cell atlas - PANX2 - The Human Protein Atlas

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PANX2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PANX2
Gene description	Pannexin 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (HDLM-2, Hep G2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA004624
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004624	Hep G2	Plasma membrane
	HPA004624	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	PANX2 (HGNC Symbol)
Synonyms	hPANX2, PX2
Description	Pannexin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50170731 - 50180294
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000073150 (version 83.38)
Entrez gene	56666
UniProt	Q96RD6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96RD6
Antibodypedia	PANX2 antibodies

PROTEIN BROWSER

PANX2-001	PANX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PANX2-001 ENSP00000159647 ENST00000159647	Q96RD6 [Direct mapping] Pannexin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0006812 [cation transport] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0022829 [wide pore channel activity] GO:0034214 [protein hexamerization] GO:0055077 [gap junction hemi-channel activity] Show all	643 aa 70.6 kDa	No	4
PANX2-002 ENSP00000379183 ENST00000395842	Q96RD6 [Direct mapping] Pannexin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002931 [response to ischemia] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0006812 [cation transport] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0015267 [channel activity] GO:0016021 [integral component of membrane] GO:0022829 [wide pore channel activity] GO:0034214 [protein hexamerization] GO:0055077 [gap junction hemi-channel activity] GO:0055085 [transmembrane transport] Show all	677 aa 74.4 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.