Expression of ABCB11 in cancer - Summary

CANCER ATLAS

Gene description

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019035

GENE INFORMATION
Gene name	ABCB11 (HGNC Symbol)
Synonyms	ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 11 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	168922938 - 169031322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073734 (version 83.38)
Entrez gene	8647
UniProt	O95342 (UniProt - Evidence at protein level)
neXtProt	NX_O95342
Antibodypedia	ABCB11 antibodies

PROTEIN BROWSER

ABCB11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB11-001 ENSP00000263817 ENST00000263817	O95342 [Direct mapping] Bile salt export pump Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006699 [bile acid biosynthetic process] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008554 [sodium-exporting ATPase activity, phosphorylative mechanism] GO:0015126 [canalicular bile acid transmembrane transporter activity] GO:0015432 [bile acid-exporting ATPase activity] GO:0015721 [bile acid and bile salt transport] GO:0015722 [canalicular bile acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0035725 [sodium ion transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0045177 [apical part of cell] GO:0046581 [intercellular canaliculus] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1321 aa 146.4 kDa	No	>9