Fields »
ABOUT
HELP
BLOG
ABCB11

GENERAL INFORMATION

Gene name

 ABCB11

Gene description

 ATP-binding cassette, sub-family B (MDR/TAP), member 11

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Group enriched (liver, testis)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in liver bile canaliculi.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019035
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 ABCB11 (HGNC Symbol)

Synonyms

 ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP

Description

 ATP-binding cassette, sub-family B (MDR/TAP), member 11 (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 168922938 - 169031322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073734 (version 83.38)

Entrez gene

 8647

UniProt

 O95342 (UniProt - Evidence at protein level)

neXtProt

 NX_O95342

Antibodypedia

 ABCB11 antibodies

PROTEIN BROWSER
ABCB11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCB11-001
ENSP00000263817
ENST00000263817
O95342 [Direct mapping]
Bile salt export pump
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006810 [transport]
GO:0008206 [bile acid metabolic process]
GO:0008554 [sodium-exporting ATPase activity, phosphorylative mechanism]
GO:0015126 [canalicular bile acid transmembrane transporter activity]
GO:0015432 [bile acid-exporting ATPase activity]
GO:0015721 [bile acid and bile salt transport]
GO:0015722 [canalicular bile acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0035725 [sodium ion transmembrane transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0046581 [intercellular canaliculus]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 1321 aa
146.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.