Expression of IGF2BP2 in cancer - Summary

CANCER ATLAS

Gene description

Insulin-like growth factor 2 mRNA binding protein 2

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA035145	CAB017126

GENE INFORMATION
Gene name	IGF2BP2 (HGNC Symbol)
Synonyms	IMP-2
Description	Insulin-like growth factor 2 mRNA binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	185643739 - 185825056
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073792 (version 83.38)
Entrez gene	10644
UniProt	Q9Y6M1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6M1
Antibodypedia	IGF2BP2 antibodies

PROTEIN BROWSER

IGF2BP2-001	IGF2BP2-002	IGF2BP2-008	IGF2BP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGF2BP2-001 ENSP00000371634 ENST00000382199	Q9Y6M1 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0009653 [anatomical structure morphogenesis] GO:0010467 [gene expression] GO:0017148 [negative regulation of translation] GO:0042035 [regulation of cytokine biosynthetic process] GO:0044822 [poly(A) RNA binding] GO:0045182 [translation regulator activity] GO:0048027 [mRNA 5'-UTR binding] GO:0051028 [mRNA transport] Show all	599 aa 66.1 kDa	No	0
IGF2BP2-002 ENSP00000320204 ENST00000346192	Q9Y6M1 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0009653 [anatomical structure morphogenesis] GO:0010467 [gene expression] GO:0017148 [negative regulation of translation] GO:0042035 [regulation of cytokine biosynthetic process] GO:0044822 [poly(A) RNA binding] GO:0045182 [translation regulator activity] GO:0048027 [mRNA 5'-UTR binding] GO:0051028 [mRNA transport] Show all	556 aa 61.8 kDa	No	0
IGF2BP2-008 ENSP00000410242 ENST00000457616	F8W930 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] Show all	605 aa 66.8 kDa	No	0
IGF2BP2-201 ENSP00000413787 ENST00000421047	Q9Y6M1 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0009653 [anatomical structure morphogenesis] GO:0010467 [gene expression] GO:0017148 [negative regulation of translation] GO:0042035 [regulation of cytokine biosynthetic process] GO:0044822 [poly(A) RNA binding] GO:0045182 [translation regulator activity] GO:0048027 [mRNA 5'-UTR binding] GO:0051028 [mRNA transport] Show all	536 aa 59 kDa	No	0