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IGF2BP2

GENERAL INFORMATION

Gene name

 IGF2BP2

Gene description

 Insulin-like growth factor 2 mRNA binding protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035145 , CAB017126
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 IGF2BP2 (HGNC Symbol)

Synonyms

 IMP-2

Description

 Insulin-like growth factor 2 mRNA binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]

Chromosome

 3

Cytoband

 q27.2

Chromosome location (bp)

 185643739 - 185825056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073792 (version 83.38)

Entrez gene

 10644

UniProt

 Q9Y6M1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6M1

Antibodypedia

 IGF2BP2 antibodies

PROTEIN BROWSER
IGF2BP2-001
IGF2BP2-002
IGF2BP2-008
IGF2BP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGF2BP2-001
ENSP00000371634
ENST00000382199
Q9Y6M1 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0009653 [anatomical structure morphogenesis]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0051028 [mRNA transport]
Show all
 599 aa
66.1 kDa 		No 0
IGF2BP2-002
ENSP00000320204
ENST00000346192
Q9Y6M1 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0009653 [anatomical structure morphogenesis]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0051028 [mRNA transport]
Show all
 556 aa
61.8 kDa 		No 0
IGF2BP2-008
ENSP00000410242
ENST00000457616
F8W930 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
Show all
 605 aa
66.8 kDa 		No 0
IGF2BP2-201
ENSP00000413787
ENST00000421047
Q9Y6M1 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0009653 [anatomical structure morphogenesis]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0051028 [mRNA transport]
Show all
 536 aa
59 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.