We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer cells showed weak to moderate cytoplasmic staining that in cases was combined with membranous and/or nuclear staining. Few cases of melanomas and prostate cancers were strongly stained. Carcinoids were negative.
Hepatocellular carcinomas showed strong cytoplasmic staining. Cases of endometrial cancers and lung adenocarcinomas showed moderate cytoplasmic positivity. Remaining cancers were mainly negative.
GENE INFORMATION
Gene name
PPP2R2C (HGNC Symbol)
Synonyms
IMYPNO, MGC33570, PR52, PR55G
Description
Protein phosphatase 2, regulatory subunit B, gamma (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
