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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PPP2R2C
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PPP2R2C

Gene description

Protein phosphatase 2, regulatory subunit B, gamma

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, caudate)
FANTOM5:Group enriched (caudate, hippocampus, brain, cerebellum, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression with high levels in several tissues including the CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 2 antibodies.
HPA042122 , HPA042770
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus, brain, cerebellum, pituitary gland)

GENE INFORMATION

Gene name

PPP2R2C (HGNC Symbol)

Synonyms

IMYPNO, MGC33570, PR52, PR55G

Description

Protein phosphatase 2, regulatory subunit B, gamma (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.1

Chromosome location (bp)

6320578 - 6563600

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074211 (version 83.38)

Entrez gene

5522

UniProt

Q9Y2T4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2T4

Antibodypedia

PPP2R2C antibodies

PROTEIN BROWSER

PPP2R2C-001
PPP2R2C-002
PPP2R2C-003
PPP2R2C-004
PPP2R2C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPP2R2C-001
ENSP00000372042
ENST00000382599
Q9Y2T4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
447 aa
51.5 kDa
No 0
PPP2R2C-002
ENSP00000335083
ENST00000335585
Q9Y2T4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
447 aa
51.4 kDa
No 0
PPP2R2C-003
ENSP00000423649
ENST00000506140
Q9Y2T4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
440 aa
50.6 kDa
No 0
PPP2R2C-004
ENSP00000425247
ENST00000507294
Q9Y2T4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
440 aa
50.6 kDa
No 0
PPP2R2C-005
ENSP00000422374
ENST00000515571
Q9Y2T4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
430 aa
49.5 kDa
No 0

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