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SCARF1

CANCER ATLAS

Gene description

 Scavenger receptor class F, member 1

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA072936

GENE INFORMATION

Gene name

 SCARF1 (HGNC Symbol)

Synonyms

 KIAA0149, SREC

Description

 Scavenger receptor class F, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1633858 - 1645747

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074660 (version 83.38)

Entrez gene

 8578

UniProt

 Q14162 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14162

Antibodypedia

 SCARF1 antibodies

PROTEIN BROWSER
SCARF1-001
SCARF1-002
SCARF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCARF1-001
ENSP00000263071
ENST00000263071
Q14162 [Direct mapping]
Scavenger receptor class F member 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006707 [cholesterol catabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030666 [endocytic vesicle membrane]
GO:0048680 [positive regulation of axon regeneration]
Show all
 830 aa
87.4 kDa 		Yes 0
SCARF1-002
ENSP00000458174
ENST00000571272
Q14162 [Direct mapping]
Scavenger receptor class F member 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006707 [cholesterol catabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016322 [neuron remodeling]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030666 [endocytic vesicle membrane]
GO:0048680 [positive regulation of axon regeneration]
Show all
 569 aa
60.8 kDa 		Yes 0
SCARF1-201
ENSP00000323964
ENST00000348987
A0A0A0MR54 [Direct mapping]
Scavenger receptor class F member 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 744 aa
78.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.