Cell atlas - SCARF1 - The Human Protein Atlas

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SCARF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SCARF1
Gene description	Scavenger receptor class F, member 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (TIME, HUVEC TERT2, REH, HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, HUVEC TERT2, REH, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SCARF1 (HGNC Symbol)
Synonyms	KIAA0149, SREC
Description	Scavenger receptor class F, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1633858 - 1645747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074660 (version 83.38)
Entrez gene	8578
UniProt	Q14162 (UniProt - Evidence at protein level)
neXtProt	NX_Q14162
Antibodypedia	SCARF1 antibodies

PROTEIN BROWSER

SCARF1-001	SCARF1-002	SCARF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCARF1-001 ENSP00000263071 ENST00000263071	Q14162 [Direct mapping] Scavenger receptor class F member 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006707 [cholesterol catabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0030169 [low-density lipoprotein particle binding] GO:0030666 [endocytic vesicle membrane] GO:0048680 [positive regulation of axon regeneration] Show all	830 aa 87.4 kDa	Yes	0
SCARF1-002 ENSP00000458174 ENST00000571272	Q14162 [Direct mapping] Scavenger receptor class F member 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006707 [cholesterol catabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0016322 [neuron remodeling] GO:0030169 [low-density lipoprotein particle binding] GO:0030666 [endocytic vesicle membrane] GO:0048680 [positive regulation of axon regeneration] Show all	569 aa 60.8 kDa	Yes	0
SCARF1-201 ENSP00000323964 ENST00000348987	A0A0A0MR54 [Direct mapping] Scavenger receptor class F member 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	744 aa 78.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.