Fields »
ABOUT
HELP
BLOG
LMAN1

GENERAL INFORMATION

Gene name

 LMAN1

Gene description

 Lectin, mannose-binding, 1

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002320 , CAB037163
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LMAN1 (HGNC Symbol)

Synonyms

 ERGIC-53, ERGIC53, F5F8D, FMFD1, gp58, MCFD1, MR60

Description

 Lectin, mannose-binding, 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]

Chromosome

 18

Cytoband

 q21.32

Chromosome location (bp)

 59327823 - 59359962

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074695 (version 83.38)

Entrez gene

 3998

UniProt

 P49257 (UniProt - Evidence at protein level)

neXtProt

 NX_P49257

Antibodypedia

 LMAN1 antibodies

PROTEIN BROWSER
LMAN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMAN1-001
ENSP00000251047
ENST00000251047
P49257 [Direct mapping]
Protein ERGIC-53
A0A024R2A7 [Target identity:100%; Query identity:100%]
Lectin, mannose-binding, 1, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0006457 [protein folding]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007029 [endoplasmic reticulum organization]
GO:0007030 [Golgi organization]
GO:0007596 [blood coagulation]
GO:0010638 [positive regulation of organelle organization]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030017 [sarcomere]
GO:0030134 [ER to Golgi transport vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044220 [host cell perinuclear region of cytoplasm]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048208 [COPII vesicle coating]
GO:0051082 [unfolded protein binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 510 aa
57.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.