Expression of ATP12A in cancer - Summary

CANCER ATLAS

Gene description

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039526

GENE INFORMATION
Gene name	ATP12A (HGNC Symbol)
Synonyms	ATP1AL1
Description	ATPase, H+/K+ transporting, nongastric, alpha polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	13
Cytoband	q12.12
Chromosome location (bp)	24680411 - 24712493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075673 (version 83.38)
Entrez gene	479
UniProt	P54707 (UniProt - Evidence at protein level)
neXtProt	NX_P54707
Antibodypedia	ATP12A antibodies

PROTEIN BROWSER

ATP12A-001	ATP12A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP12A-001 ENSP00000371372 ENST00000381946	P54707 [Direct mapping] Potassium-transporting ATPase alpha chain 2 Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005889 [hydrogen:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0008152 [metabolic process] GO:0008900 [hydrogen:potassium-exchanging ATPase activity] GO:0010107 [potassium ion import] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	1039 aa 115.5 kDa	No	>9
ATP12A-201 ENSP00000218548 ENST00000218548	P54707 [Direct mapping] Potassium-transporting ATPase alpha chain 2 Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005889 [hydrogen:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006885 [regulation of pH] GO:0008152 [metabolic process] GO:0008900 [hydrogen:potassium-exchanging ATPase activity] GO:0010038 [response to metal ion] GO:0010107 [potassium ion import] GO:0014070 [response to organic cyclic compound] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030001 [metal ion transport] GO:0030007 [cellular potassium ion homeostasis] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] Show all	1045 aa 116.1 kDa	No	>9