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ATP12A

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GENERAL INFORMATION

Gene name

 ATP12A

Gene description

 ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ATP12A (HGNC Symbol)

Synonyms

 ATP1AL1

Description

 ATPase, H+/K+ transporting, nongastric, alpha polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 13

Cytoband

 q12.12

Chromosome location (bp)

 24680411 - 24712493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075673 (version 83.38)

Entrez gene

 479

UniProt

 P54707 (UniProt - Evidence at protein level)

neXtProt

 NX_P54707

Antibodypedia

 ATP12A antibodies

PROTEIN BROWSER
ATP12A-001
ATP12A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP12A-001
ENSP00000371372
ENST00000381946
P54707 [Direct mapping]
Potassium-transporting ATPase alpha chain 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005889 [hydrogen:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0008152 [metabolic process]
GO:0008900 [hydrogen:potassium-exchanging ATPase activity]
GO:0010107 [potassium ion import]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
Show all
 1039 aa
115.5 kDa 		No >9
ATP12A-201
ENSP00000218548
ENST00000218548
P54707 [Direct mapping]
Potassium-transporting ATPase alpha chain 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005889 [hydrogen:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006885 [regulation of pH]
GO:0008152 [metabolic process]
GO:0008900 [hydrogen:potassium-exchanging ATPase activity]
GO:0010038 [response to metal ion]
GO:0010107 [potassium ion import]
GO:0014070 [response to organic cyclic compound]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030001 [metal ion transport]
GO:0030007 [cellular potassium ion homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
Show all
 1045 aa
116.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.