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Cancer cells displayed moderate to strong cytoplasmic positivity and additional membranous staining in a few cases. Hepatocellular carcinomas were weakly stained or negative.
Several cases of carcinoids, gliomas and testicular cancers along with a few cases of melanomas, squamous cell carcinomas, breast and prostate cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were negative.
Cancer tissues displayed weak to moderate cytoplasmic staining with additional membranous and nuclear positivity in several tissues. Rare case of glioma and ovarian cancer was strongly stained. Majority of the cases of renal cancers were negative.
Cancer cells generally showed moderate to strong cytoplasmic immunoreactivity. A majority of hepatocellular and pancreatic cancers as well as several lung, urothelial, renal and gastric cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TUBA3D (HGNC Symbol)
Synonyms
H2-ALPHA
Description
Tubulin, alpha 3d (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle formation during mitosis. [provided by RefSeq, Oct 2011]
