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Colorectal, breast, prostate, testis and gynaecological cancers showed moderate to strong cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
MAP2K7 (HGNC Symbol)
Synonyms
Jnkk2, MKK7, PRKMK7
Description
Mitogen-activated protein kinase kinase 7 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
O14733 [Direct mapping] Dual specificity mitogen-activated protein kinase kinase 7
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)