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MAP2K7

GENERAL INFORMATION

Gene name

 MAP2K7

Gene description

 Mitogen-activated protein kinase kinase 7

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001633 , CAB004262
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP2K7 (HGNC Symbol)

Synonyms

 Jnkk2, MKK7, PRKMK7

Description

 Mitogen-activated protein kinase kinase 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7903843 - 7914478

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076984 (version 83.38)

Entrez gene

 5609

UniProt

 O14733 (UniProt - Evidence at protein level)

neXtProt

 NX_O14733

Antibodypedia

 MAP2K7 antibodies

PROTEIN BROWSER
MAP2K7-001
MAP2K7-002
MAP2K7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP2K7-001
ENSP00000381068
ENST00000397981
O14733 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 7
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006970 [response to osmotic stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0008545 [JUN kinase kinase activity]
GO:0009408 [response to heat]
GO:0009411 [response to UV]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0051403 [stress-activated MAPK cascade]
Show all
 426 aa
48.2 kDa 		No 0
MAP2K7-002
ENSP00000381066
ENST00000397979
O14733 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006970 [response to osmotic stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0008545 [JUN kinase kinase activity]
GO:0009408 [response to heat]
GO:0009411 [response to UV]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0051403 [stress-activated MAPK cascade]
Show all
 419 aa
47.5 kDa 		No 0
MAP2K7-003
ENSP00000381070
ENST00000397983
O14733 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006970 [response to osmotic stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0008022 [protein C-terminus binding]
GO:0008545 [JUN kinase kinase activity]
GO:0009408 [response to heat]
GO:0009411 [response to UV]
GO:0009611 [response to wounding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0051403 [stress-activated MAPK cascade]
GO:0072709 [cellular response to sorbitol]
GO:2000671 [regulation of motor neuron apoptotic process]
Show all
 435 aa
49.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.