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DNAJC10

CANCER ATLAS

Gene description

 DnaJ (Hsp40) homolog, subfamily C, member 10

Protein class

 Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031111

GENE INFORMATION

Gene name

 DNAJC10 (HGNC Symbol)

Synonyms

 ERdj5, PDIA19

Description

 DnaJ (Hsp40) homolog, subfamily C, member 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Chromosome

 2

Cytoband

 q32.1

Chromosome location (bp)

 182716041 - 182794464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077232 (version 83.38)

Entrez gene

 54431

UniProt

 Q8IXB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IXB1

Antibodypedia

 DNAJC10 antibodies

PROTEIN BROWSER
DNAJC10-001
DNAJC10-201
DNAJC10-202
DNAJC10-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJC10-001
ENSP00000264065
ENST00000264065
Q8IXB1 [Direct mapping]
DnaJ homolog subfamily C member 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0051787 [misfolded protein binding]
GO:0055114 [oxidation-reduction process]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
Show all
 793 aa
91.1 kDa 		No 1
DNAJC10-201
ENSP00000441560
ENST00000537515
Q8IXB1 [Direct mapping]
DnaJ homolog subfamily C member 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0051787 [misfolded protein binding]
GO:0055114 [oxidation-reduction process]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
Show all
 332 aa
37.7 kDa 		No 1
DNAJC10-202
ENSP00000481044
ENST00000613960
A0A087WXH7 [Direct mapping]
DnaJ homolog subfamily C member 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005623 [cell]
GO:0016021 [integral component of membrane]
GO:0045454 [cell redox homeostasis]
Show all
 177 aa
20.8 kDa 		No 1
DNAJC10-203
ENSP00000479930
ENST00000616986
Q8IXB1 [Direct mapping]
DnaJ homolog subfamily C member 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0051787 [misfolded protein binding]
GO:0055114 [oxidation-reduction process]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
Show all
 747 aa
86.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.