Cell atlas - DNAJC10 - The Human Protein Atlas

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DNAJC10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	DNAJC10
Gene description	DnaJ (Hsp40) homolog, subfamily C, member 10
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	DNAJC10 (HGNC Symbol)
Synonyms	ERdj5, PDIA19
Description	DnaJ (Hsp40) homolog, subfamily C, member 10 (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Chromosome	2
Cytoband	q32.1
Chromosome location (bp)	182716041 - 182794464
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077232 (version 83.38)
Entrez gene	54431
UniProt	Q8IXB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXB1
Antibodypedia	DNAJC10 antibodies

PROTEIN BROWSER

DNAJC10-001	DNAJC10-201	DNAJC10-202	DNAJC10-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJC10-001 ENSP00000264065 ENST00000264065	Q8IXB1 [Direct mapping] DnaJ homolog subfamily C member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015036 [disulfide oxidoreductase activity] GO:0016020 [membrane] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030544 [Hsp70 protein binding] GO:0032781 [positive regulation of ATPase activity] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0034975 [protein folding in endoplasmic reticulum] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] GO:0051087 [chaperone binding] GO:0051117 [ATPase binding] GO:0051787 [misfolded protein binding] GO:0055114 [oxidation-reduction process] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	793 aa 91.1 kDa	No	1
DNAJC10-201 ENSP00000441560 ENST00000537515	Q8IXB1 [Direct mapping] DnaJ homolog subfamily C member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015036 [disulfide oxidoreductase activity] GO:0016020 [membrane] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030544 [Hsp70 protein binding] GO:0032781 [positive regulation of ATPase activity] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0034975 [protein folding in endoplasmic reticulum] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] GO:0051087 [chaperone binding] GO:0051117 [ATPase binding] GO:0051787 [misfolded protein binding] GO:0055114 [oxidation-reduction process] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	332 aa 37.7 kDa	No	1
DNAJC10-202 ENSP00000481044 ENST00000613960	A0A087WXH7 [Direct mapping] DnaJ homolog subfamily C member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	177 aa 20.8 kDa	No	1
DNAJC10-203 ENSP00000479930 ENST00000616986	Q8IXB1 [Direct mapping] DnaJ homolog subfamily C member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015036 [disulfide oxidoreductase activity] GO:0016020 [membrane] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030544 [Hsp70 protein binding] GO:0032781 [positive regulation of ATPase activity] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0034975 [protein folding in endoplasmic reticulum] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] GO:0051087 [chaperone binding] GO:0051117 [ATPase binding] GO:0051787 [misfolded protein binding] GO:0055114 [oxidation-reduction process] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] Show all	747 aa 86.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.