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FBLN1

GENERAL INFORMATION

Gene name

 FBLN1

Gene description

 Fibulin 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Positivity in extracellular matrix and plasma. Cytoplasmic expression in several tissues, including endometrium and placenta.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 4 antibodies.
HPA001612 , HPA001613 , CAB004393 , CAB068187
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FBLN1 (HGNC Symbol)

Synonyms

 FBLN

Description

 Fibulin 1 (HGNC Symbol)

Entrez gene summary

 Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45502238 - 45601135

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077942 (version 83.38)

Entrez gene

 2192

UniProt

 P23142 (UniProt - Evidence at protein level)

neXtProt

 NX_P23142

Antibodypedia

 FBLN1 antibodies

PROTEIN BROWSER
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FBLN1-001
FBLN1-002
FBLN1-003
FBLN1-004
FBLN1-005
FBLN1-006
FBLN1-008
FBLN1-010
FBLN1-011
FBLN1-018
FBLN1-019
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBLN1-001
ENSP00000331544
ENST00000327858
P23142 [Direct mapping]
Fibulin-1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007162 [negative regulation of cell adhesion]
GO:0007566 [embryo implantation]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016032 [viral process]
GO:0016504 [peptidase activator activity]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0070051 [fibrinogen binding]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071953 [elastic fiber]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1904188 [negative regulation of transformation of host cell by virus]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2000146 [negative regulation of cell motility]
GO:2000647 [negative regulation of stem cell proliferation]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 703 aa
77.2 kDa 		Yes 0
FBLN1-002
ENSP00000385521
ENST00000402984
B1AHL2 [Direct mapping]
Fibulin-1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0010952 [positive regulation of peptidase activity]
GO:0016504 [peptidase activator activity]
GO:0030198 [extracellular matrix organization]
Show all
 721 aa
78.3 kDa 		Yes 0
FBLN1-003
ENSP00000262722
ENST00000262722
P23142 [Direct mapping]
Fibulin-1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007162 [negative regulation of cell adhesion]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016032 [viral process]
GO:0016504 [peptidase activator activity]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0070051 [fibrinogen binding]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071953 [elastic fiber]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1904188 [negative regulation of transformation of host cell by virus]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2000146 [negative regulation of cell motility]
GO:2000647 [negative regulation of stem cell proliferation]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 683 aa
74.4 kDa 		Yes 0
FBLN1-004
ENSP00000393812
ENST00000442170
P23142 [Direct mapping]
Fibulin-1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007162 [negative regulation of cell adhesion]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016032 [viral process]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0070051 [fibrinogen binding]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071953 [elastic fiber]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1904188 [negative regulation of transformation of host cell by virus]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2000146 [negative regulation of cell motility]
GO:2000647 [negative regulation of stem cell proliferation]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 601 aa
65.4 kDa 		Yes 0
FBLN1-005
ENSP00000402963
ENST00000455233
B1AHN3 [Direct mapping]
Fibulin-1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
 172 aa
18.4 kDa 		Yes 0
FBLN1-006
ENSP00000404024
ENST00000445110
B1AHM6 [Direct mapping]
Fibulin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
7.2 kDa 		No 0
FBLN1-008
ENSP00000415289
ENST00000411478
B1AHM9 [Direct mapping]
Fibulin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
 189 aa
20.5 kDa 		No 0
FBLN1-010
ENSP00000414584
ENST00000454279
B1AHM7 [Direct mapping]
Fibulin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
 139 aa
15.4 kDa 		No 0
FBLN1-011
ENSP00000415160
ENST00000451475
B1AHM8 [Direct mapping]
Fibulin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
Show all
 181 aa
19.4 kDa 		No 0
FBLN1-018
ENSP00000489422
ENST00000460300
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.9 kDa 		No 0
FBLN1-019
ENSP00000342212
ENST00000340923
P23142 [Direct mapping]
Fibulin-1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007162 [negative regulation of cell adhesion]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016032 [viral process]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0070051 [fibrinogen binding]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071953 [elastic fiber]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1904188 [negative regulation of transformation of host cell by virus]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2000146 [negative regulation of cell motility]
GO:2000647 [negative regulation of stem cell proliferation]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 566 aa
61.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.