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This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002931 [response to ischemia] GO:0003824 [catalytic activity] GO:0004083 [bisphosphoglycerate 2-phosphatase activity] GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0006003 [fructose 2,6-bisphosphate metabolic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008152 [metabolic process] GO:0009410 [response to xenobiotic stimulus] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030388 [fructose 1,6-bisphosphate metabolic process] GO:0043069 [negative regulation of programmed cell death] GO:0043456 [regulation of pentose-phosphate shunt] GO:0045739 [positive regulation of DNA repair] GO:0045820 [negative regulation of glycolytic process] GO:0060576 [intestinal epithelial cell development] GO:0071279 [cellular response to cobalt ion] GO:0071456 [cellular response to hypoxia] GO:1901215 [negative regulation of neuron death] GO:1901525 [negative regulation of macromitophagy] GO:1902153 [regulation of response to DNA damage checkpoint signaling] GO:1903301 [positive regulation of hexokinase activity] GO:1904024 [negative regulation of glucose catabolic process to lactate via pyruvate] GO:2000378 [negative regulation of reactive oxygen species metabolic process]