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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TIGAR
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TIGAR

Gene description

TP53 induced glycolysis regulatory phosphatase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA040354 , HPA044111 , CAB034010
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

TIGAR (HGNC Symbol)

Synonyms

C12orf5

Description

TP53 induced glycolysis regulatory phosphatase (HGNC Symbol)

Entrez gene summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.32

Chromosome location (bp)

4307763 - 4354593

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078237 (version 83.38)

Entrez gene

57103

UniProt

Q9NQ88 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NQ88

Antibodypedia

TIGAR antibodies

PROTEIN BROWSER

TIGAR-001
TIGAR-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TIGAR-001
ENSP00000179259
ENST00000179259
Q9NQ88 [Direct mapping]
Fructose-2,6-bisphosphatase TIGAR
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002931 [response to ischemia]
GO:0003824 [catalytic activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008152 [metabolic process]
GO:0009410 [response to xenobiotic stimulus]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0045739 [positive regulation of DNA repair]
GO:0045820 [negative regulation of glycolytic process]
GO:0060576 [intestinal epithelial cell development]
GO:0071279 [cellular response to cobalt ion]
GO:0071456 [cellular response to hypoxia]
GO:1901215 [negative regulation of neuron death]
GO:1901525 [negative regulation of macromitophagy]
GO:1902153 [regulation of response to DNA damage checkpoint signaling]
GO:1903301 [positive regulation of hexokinase activity]
GO:1904024 [negative regulation of glucose catabolic process to lactate via pyruvate]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
270 aa
30.1 kDa
No 0
TIGAR-004
ENSP00000488928
ENST00000635110
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
211 aa
23.6 kDa
No 0

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