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ADCY2

GENERAL INFORMATION

Gene name

 ADCY2

Gene description

 Adenylate cyclase 2 (brain)

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues, most abundant in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA038015 , HPA038483 , CAB031482
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ADCY2 (HGNC Symbol)

Synonyms

 AC2, HBAC2, KIAA1060

Description

 Adenylate cyclase 2 (brain) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 7396208 - 7830081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078295 (version 83.38)

Entrez gene

 108

UniProt

 Q08462 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08462

Antibodypedia

 ADCY2 antibodies

PROTEIN BROWSER
ADCY2-001
ADCY2-008
ADCY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCY2-001
ENSP00000342952
ENST00000338316
Q08462 [Direct mapping]
Adenylate cyclase type 2
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0030145 [manganese ion binding]
GO:0030425 [dendrite]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:1904322 [cellular response to forskolin]
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 1091 aa
123.6 kDa 		No >9
ADCY2-008
ENSP00000425069
ENST00000515681
D6REB8 [Direct mapping]
Adenylate cyclase type 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 100 aa
11.5 kDa 		No 0
ADCY2-201
ENSP00000444803
ENST00000537121
A0A0A0MTM9 [Direct mapping]
Adenylate cyclase type 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 1089 aa
123.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.