Fields »
ABOUT
HELP
BLOG
RBFOX1

GENERAL INFORMATION

Gene name

 RBFOX1

Gene description

 RNA binding protein, fox-1 homolog (C. elegans) 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx:Group enriched (cerebral cortex, caudate, skeletal muscle, cerebellum, hippocampus, heart muscle, hypothalamus)
FANTOM5:Tissue enhanced (caudate, cerebellum, skeletal muscle, brain)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in CNS and heart muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA040809
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, caudate, skeletal muscle, cerebellum, hippocampus, heart muscle, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, skeletal muscle, brain)

GENE INFORMATION

Gene name

 RBFOX1 (HGNC Symbol)

Synonyms

 A2BP1, FOX-1, HRNBP1

Description

 RNA binding protein, fox-1 homolog (C. elegans) 1 (HGNC Symbol)

Entrez gene summary

 The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 6019094 - 7713338

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078328 (version 83.38)

Entrez gene

 54715

UniProt

 Q9NWB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NWB1

Antibodypedia

 RBFOX1 antibodies

PROTEIN BROWSER
«
RBFOX1-001
RBFOX1-002
RBFOX1-003
RBFOX1-004
RBFOX1-005
RBFOX1-006
RBFOX1-007
RBFOX1-008
RBFOX1-009
RBFOX1-010
RBFOX1-011
RBFOX1-014
RBFOX1-018
RBFOX1-019
RBFOX1-201
RBFOX1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBFOX1-001
ENSP00000309117
ENST00000311745
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 418 aa
44.8 kDa 		No 0
RBFOX1-002
ENSP00000347855
ENST00000355637
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 395 aa
42.4 kDa 		No 0
RBFOX1-003
ENSP00000450031
ENST00000550418
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 397 aa
42.8 kDa 		No 0
RBFOX1-004
ENSP00000447753
ENST00000553186
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 370 aa
40 kDa 		No 0
RBFOX1-005
ENSP00000438768
ENST00000535565
F5H0M1 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0003723 [RNA binding]
GO:0043484 [regulation of RNA splicing]
Show all
 380 aa
40.8 kDa 		No 0
RBFOX1-006
ENSP00000448496
ENST00000552089
F8VRS4 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0043484 [regulation of RNA splicing]
Show all
 391 aa
42.3 kDa 		No 0
RBFOX1-007
ENSP00000447281
ENST00000551752
F8VZY7 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 263 aa
28.6 kDa 		No 0
RBFOX1-008
ENSP00000447717
ENST00000547338
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 397 aa
42.8 kDa 		No 0
RBFOX1-009
ENSP00000391269
ENST00000422070
B7Z1U7 [Direct mapping]
RNA binding protein fox-1 homolog
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050885 [neuromuscular process controlling balance]
Show all
 425 aa
45.9 kDa 		No 0
RBFOX1-010
ENSP00000446842
ENST00000547372
F8VZG9 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0043484 [regulation of RNA splicing]
Show all
 466 aa
50.6 kDa 		No 0
RBFOX1-011
ENSP00000402745
ENST00000436368
Q9NWB1 [Direct mapping]
RNA binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0006397 [mRNA processing]
GO:0007399 [nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
GO:0050658 [RNA transport]
Show all
 392 aa
42.1 kDa 		No 0
RBFOX1-014
ENSP00000450402
ENST00000547605
F8VR27 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 262 aa
28.4 kDa 		No 0
RBFOX1-018
ENSP00000454250
ENST00000567470
H3BM62 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
 74 aa
7.8 kDa 		No 0
RBFOX1-019
ENSP00000458748
ENST00000570626
I3L1D4 [Direct mapping]
RNA-binding protein fox-1 homolog 1
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 189 aa
20.7 kDa 		No 0
RBFOX1-201
ENSP00000344196
ENST00000340209
J3KNW3 [Direct mapping]
RNA binding protein fox-1 homolog
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
Show all
 402 aa
43.1 kDa 		No 0
RBFOX1-202
ENSP00000484837
ENST00000620507
A0A087X2B1 [Direct mapping]
RNA binding protein fox-1 homolog
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0043484 [regulation of RNA splicing]
Show all
 375 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.