Most cancer tissues were negative. Strong membranous and cytoplasmic staining was observed in all colorectal cancers while several cases of cholangiocarcinomas, gastric, pancreatic and ovarian cancers displayed moderate to strong immunoreactivity.
CDH17 (HGNC Symbol)
Cadherin 17, LI cadherin (liver-intestine) (HGNC Symbol)
Entrez gene summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]