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CDH17

GENERAL INFORMATION

Gene name

 CDH17

Gene description

 Cadherin 17, LI cadherin (liver-intestine)

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine, rectum, colon)
GTEx:Group enriched (small intestine, colon)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct membranous and cytoplasmic expression in gastrointestinal glands.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA023614 , HPA023616 , HPA026556 , CAB025143
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine, rectum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 CDH17 (HGNC Symbol)

Synonyms

 cadherin, HPT-1

Description

 Cadherin 17, LI cadherin (liver-intestine) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Chromosome

 8

Cytoband

 q22.1

Chromosome location (bp)

 94127171 - 94217303

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079112 (version 83.38)

Entrez gene

 1015

UniProt

 Q12864 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q12864

Antibodypedia

 CDH17 antibodies

PROTEIN BROWSER
CDH17-001
CDH17-002
CDH17-003
CDH17-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDH17-001
ENSP00000027335
ENST00000027335
Q12864 [Direct mapping]
Cadherin-17
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006857 [oligopeptide transport]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035672 [oligopeptide transmembrane transport]
GO:0045216 [cell-cell junction organization]
Show all
 832 aa
92.2 kDa 		Yes 1
CDH17-002
ENSP00000392811
ENST00000441892
E7EN24 [Direct mapping]
Cadherin-17
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 580 aa
64.2 kDa 		Yes 0
CDH17-003
ENSP00000401468
ENST00000450165
Q12864 [Direct mapping]
Cadherin-17
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006857 [oligopeptide transport]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035672 [oligopeptide transmembrane transport]
GO:0045216 [cell-cell junction organization]
Show all
 832 aa
92.2 kDa 		Yes 1
CDH17-004
ENSP00000428189
ENST00000521491
E5RJT3 [Direct mapping]
Cadherin-17
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
 147 aa
16.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.