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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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THOC1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

THOC1

Gene description

THO complex 1

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in several tissues at variable levels, which in some tissues was combined with cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA019096 , HPA019687
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

THOC1 (HGNC Symbol)

Synonyms

HPR1, P84

Description

THO complex 1 (HGNC Symbol)

Entrez gene summary

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

Chromosome

18

Cytoband

p11.32

Chromosome location (bp)

214520 - 268050

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000079134 (version 83.38)

Entrez gene

9984

UniProt

Q96FV9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96FV9

Antibodypedia

THOC1 antibodies

PROTEIN BROWSER

THOC1-001
THOC1-014
THOC1-020
THOC1-201
THOC1-202
THOC1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THOC1-001
ENSP00000261600
ENST00000261600
Q96FV9 [Direct mapping]
THO complex subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000018 [regulation of DNA recombination]
GO:0000346 [transcription export complex]
GO:0000347 [THO complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008380 [RNA splicing]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0031297 [replication fork processing]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0045171 [intercellular bridge]
GO:0046784 [viral mRNA export from host cell nucleus]
GO:0048297 [negative regulation of isotype switching to IgA isotypes]
GO:2000002 [negative regulation of DNA damage checkpoint]
Show all
657 aa
75.7 kDa
No 0
THOC1-014
ENSP00000473499
ENST00000584642
R4GN58 [Direct mapping]
THO complex subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
95 aa
11.2 kDa
No 0
THOC1-020
ENSP00000473276
ENST00000579891
R4GMN4 [Direct mapping]
THO complex subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
272 aa
31.9 kDa
No 0
THOC1-201
ENSP00000480460
ENST00000616322
A0A087WWS1 [Direct mapping]
THO complex subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
657 aa
75.7 kDa
No 0
THOC1-202
ENSP00000481599
ENST00000621904
A0A087WY84 [Direct mapping]
THO complex subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
360 aa
41.5 kDa
No 0
THOC1-203
ENSP00000486359
ENST00000631280
J3QQZ3 [Direct mapping]
THO complex subunit 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
121 aa
14.1 kDa
No 1

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