Cell atlas - MKNK1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MKNK1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MKNK1
Gene description	MAP kinase interacting serine/threonine kinase 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA071293
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071293	HaCaT	Nucleoplasm
	HPA071293	RT4	Nucleoplasm
	HPA071293	U-2 OS	No staining

GENE INFORMATION
Gene name	MKNK1 (HGNC Symbol)
Synonyms	MNK1
Description	MAP kinase interacting serine/threonine kinase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	46557408 - 46616843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079277 (version 83.38)
Entrez gene	8569
UniProt	Q9BUB5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUB5
Antibodypedia	MKNK1 antibodies

PROTEIN BROWSER

MKNK1-001	MKNK1-004	MKNK1-010	MKNK1-014	MKNK1-016	MKNK1-018	MKNK1-019	MKNK1-020	MKNK1-022	MKNK1-026	MKNK1-027	MKNK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKNK1-001 ENSP00000361014 ENST00000371946	Q9BUB5 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006417 [regulation of translation] GO:0006446 [regulation of translational initiation] GO:0006468 [protein phosphorylation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	465 aa 51.3 kDa	No	1
MKNK1-004 ENSP00000361013 ENST00000371945	Q9BUB5 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] Show all	424 aa 47.4 kDa	No	1
MKNK1-010 ENSP00000434834 ENST00000465783	E9PN34 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	91 aa 10 kDa	No	0
MKNK1-014 ENSP00000436709 ENST00000496619	E9PIA0 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	178 aa 20.3 kDa	No	0
MKNK1-016 ENSP00000411135 ENST00000428112	Q9BUB5 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] Show all	347 aa 39.1 kDa	No	1
MKNK1-018 ENSP00000435163 ENST00000529170	E9PLE7 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	101 aa 11.4 kDa	No	0
MKNK1-019 ENSP00000431985 ENST00000532110	E9PII5 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	126 aa 14 kDa	No	0
MKNK1-020 ENSP00000434021 ENST00000531769	E9PSE0 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	100 aa 11.3 kDa	No	0
MKNK1-022 ENSP00000432665 ENST00000528237	E9PPI6 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	143 aa 16.4 kDa	No	0
MKNK1-026 ENSP00000435069 ENST00000524749	H0YE67 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	85 aa 9.3 kDa	No	0
MKNK1-027 ENSP00000431837 ENST00000532783	E9PJH1 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	171 aa 19.5 kDa	No	0
MKNK1-201 ENSP00000339573 ENST00000341183	Q7Z319 [Direct mapping] MAP kinase-interacting serine/threonine-protein kinase 1; Putative uncharacterized protein DKFZp686E14208 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0009931 [calcium-dependent protein serine/threonine kinase activity] GO:0046777 [protein autophosphorylation] Show all	329 aa 36.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.