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MKNK1

GENERAL INFORMATION

Gene name

 MKNK1

Gene description

 MAP kinase interacting serine/threonine kinase 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MKNK1 (HGNC Symbol)

Synonyms

 MNK1

Description

 MAP kinase interacting serine/threonine kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 1

Cytoband

 p33

Chromosome location (bp)

 46557408 - 46616843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079277 (version 83.38)

Entrez gene

 8569

UniProt

 Q9BUB5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUB5

Antibodypedia

 MKNK1 antibodies

PROTEIN BROWSER
«
MKNK1-001
MKNK1-004
MKNK1-010
MKNK1-014
MKNK1-016
MKNK1-018
MKNK1-019
MKNK1-020
MKNK1-022
MKNK1-026
MKNK1-027
MKNK1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKNK1-001
ENSP00000361014
ENST00000371946
Q9BUB5 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0006468 [protein phosphorylation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 465 aa
51.3 kDa 		No 1
MKNK1-004
ENSP00000361013
ENST00000371945
Q9BUB5 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
Show all
 424 aa
47.4 kDa 		No 1
MKNK1-010
ENSP00000434834
ENST00000465783
E9PN34 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 91 aa
10 kDa 		No 0
MKNK1-014
ENSP00000436709
ENST00000496619
E9PIA0 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 178 aa
20.3 kDa 		No 0
MKNK1-016
ENSP00000411135
ENST00000428112
Q9BUB5 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
Show all
 347 aa
39.1 kDa 		No 1
MKNK1-018
ENSP00000435163
ENST00000529170
E9PLE7 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 101 aa
11.4 kDa 		No 0
MKNK1-019
ENSP00000431985
ENST00000532110
E9PII5 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 126 aa
14 kDa 		No 0
MKNK1-020
ENSP00000434021
ENST00000531769
E9PSE0 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 100 aa
11.3 kDa 		No 0
MKNK1-022
ENSP00000432665
ENST00000528237
E9PPI6 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 143 aa
16.4 kDa 		No 0
MKNK1-026
ENSP00000435069
ENST00000524749
H0YE67 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 85 aa
9.3 kDa 		No 0
MKNK1-027
ENSP00000431837
ENST00000532783
E9PJH1 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 171 aa
19.5 kDa 		No 0
MKNK1-201
ENSP00000339573
ENST00000341183
Q7Z319 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 1; Putative uncharacterized protein DKFZp686E14208
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 329 aa
36.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.