Expression of LIPE in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Lipase, hormone-sensitive

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB017700

GENE INFORMATION
Gene name	LIPE (HGNC Symbol)
Synonyms	HSL
Description	Lipase, hormone-sensitive (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42401507 - 42427426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079435 (version 83.38)
Entrez gene	3991
UniProt	Q05469 (UniProt - Evidence at protein level)
neXtProt	NX_Q05469
Antibodypedia	LIPE antibodies

PROTEIN BROWSER

LIPE-001	LIPE-002	LIPE-003	LIPE-005	LIPE-006	LIPE-007	LIPE-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPE-001 ENSP00000244289 ENST00000244289	Q05469 [Direct mapping] Hormone-sensitive lipase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005515 [protein binding] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0008152 [metabolic process] GO:0008203 [cholesterol metabolic process] GO:0016042 [lipid catabolic process] GO:0016298 [lipase activity] GO:0016787 [hydrolase activity] GO:0019433 [triglyceride catabolic process] GO:0019901 [protein kinase binding] GO:0033878 [hormone-sensitive lipase activity] GO:0042758 [long-chain fatty acid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046340 [diacylglycerol catabolic process] Show all	1076 aa 116.6 kDa	No	0
LIPE-002 ENSP00000469990 ENST00000599783	M0QYP8 [Direct mapping] Hormone-sensitive lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008203 [cholesterol metabolic process] GO:0016042 [lipid catabolic process] GO:0016298 [lipase activity] Show all	260 aa 28.7 kDa	No	0
LIPE-003 ENSP00000469268 ENST00000597001	M0QXM5 [Direct mapping] Hormone-sensitive lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008203 [cholesterol metabolic process] GO:0016042 [lipid catabolic process] GO:0016298 [lipase activity] Show all	176 aa 19.6 kDa	No	0
LIPE-005 ENSP00000472531 ENST00000599211	M0R2G1 [Direct mapping] Hormone-sensitive lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008203 [cholesterol metabolic process] GO:0016042 [lipid catabolic process] GO:0016298 [lipase activity] Show all	222 aa 24.7 kDa	No	0
LIPE-006 ENSP00000469545 ENST00000597620	M0QY29 [Direct mapping] Hormone-sensitive lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	305 aa 32.6 kDa	No	0
LIPE-007 ENSP00000472218 ENST00000599918	M0R201 [Direct mapping] Hormone-sensitive lipase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		275 aa 29.2 kDa	No	0
LIPE-009 ENSP00000469030 ENST00000601189	M0QXB1 [Direct mapping] Hormone-sensitive lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008203 [cholesterol metabolic process] GO:0016042 [lipid catabolic process] GO:0016298 [lipase activity] Show all	80 aa 8.6 kDa	No	0