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LIPE

GENERAL INFORMATION

Gene name

 LIPE

Gene description

 Lipase, hormone-sensitive

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adipose tissue)
GTEx:Group enriched (adipose tissue, breast, testis)
FANTOM5:Tissue enhanced (adipose tissue, breast)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in adipocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
CAB017700
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, breast)

GENE INFORMATION

Gene name

 LIPE (HGNC Symbol)

Synonyms

 HSL

Description

 Lipase, hormone-sensitive (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 42401507 - 42427426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079435 (version 83.38)

Entrez gene

 3991

UniProt

 Q05469 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05469

Antibodypedia

 LIPE antibodies

PROTEIN BROWSER
LIPE-001
LIPE-002
LIPE-003
LIPE-005
LIPE-006
LIPE-007
LIPE-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIPE-001
ENSP00000244289
ENST00000244289
Q05469 [Direct mapping]
Hormone-sensitive lipase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004806 [triglyceride lipase activity]
GO:0005515 [protein binding]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0008152 [metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0016042 [lipid catabolic process]
GO:0016298 [lipase activity]
GO:0016787 [hydrolase activity]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0033878 [hormone-sensitive lipase activity]
GO:0042758 [long-chain fatty acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046340 [diacylglycerol catabolic process]
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 1076 aa
116.6 kDa 		No 0
LIPE-002
ENSP00000469990
ENST00000599783
M0QYP8 [Direct mapping]
Hormone-sensitive lipase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008203 [cholesterol metabolic process]
GO:0016042 [lipid catabolic process]
GO:0016298 [lipase activity]
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 260 aa
28.7 kDa 		No 0
LIPE-003
ENSP00000469268
ENST00000597001
M0QXM5 [Direct mapping]
Hormone-sensitive lipase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008203 [cholesterol metabolic process]
GO:0016042 [lipid catabolic process]
GO:0016298 [lipase activity]
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 176 aa
19.6 kDa 		No 0
LIPE-005
ENSP00000472531
ENST00000599211
M0R2G1 [Direct mapping]
Hormone-sensitive lipase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008203 [cholesterol metabolic process]
GO:0016042 [lipid catabolic process]
GO:0016298 [lipase activity]
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 222 aa
24.7 kDa 		No 0
LIPE-006
ENSP00000469545
ENST00000597620
M0QY29 [Direct mapping]
Hormone-sensitive lipase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 305 aa
32.6 kDa 		No 0
LIPE-007
ENSP00000472218
ENST00000599918
M0R201 [Direct mapping]
Hormone-sensitive lipase
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 275 aa
29.2 kDa 		No 0
LIPE-009
ENSP00000469030
ENST00000601189
M0QXB1 [Direct mapping]
Hormone-sensitive lipase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008203 [cholesterol metabolic process]
GO:0016042 [lipid catabolic process]
GO:0016298 [lipase activity]
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 80 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.