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Moderate to strong cytoplasmic and nuclear positivity was observed in several hepatocellular carcinomas. Renal and prostate cancers along with a few adenocarcinomas of lung, papillary adenocarcinomas of thyroid, ovarian and endometrial cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.
Liver, renal, skin and prostate cancers showed showed moderate to strong cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
PGM1
Synonyms
Description
Phosphoglucomutase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]
Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
