Expression of RAB21 in cancer - Summary

CANCER ATLAS

Gene description

RAB21, member RAS oncogene family

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA016988	CAB037048

GENE INFORMATION
Gene name	RAB21 (HGNC Symbol)
Synonyms	KIAA0118
Description	RAB21, member RAS oncogene family (HGNC Symbol)
Entrez gene summary	This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
Chromosome	12
Cytoband	q21.1
Chromosome location (bp)	71754874 - 71800285
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080371 (version 83.38)
Entrez gene	23011
UniProt	Q9UL25 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL25
Antibodypedia	RAB21 antibodies

PROTEIN BROWSER

RAB21-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAB21-001 ENSP00000261263 ENST00000261263	Q9UL25 [Direct mapping] Ras-related protein Rab-21 A0A024RBA9 [Target identity:100%; Query identity:100%] RAB21, member RAS oncogene family, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005802 [trans-Golgi network] GO:0005925 [focal adhesion] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008089 [anterograde axon cargo transport] GO:0009898 [cytoplasmic side of plasma membrane] GO:0012506 [vesicle membrane] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017157 [regulation of exocytosis] GO:0019003 [GDP binding] GO:0030516 [regulation of axon extension] GO:0030659 [cytoplasmic vesicle membrane] GO:0032154 [cleavage furrow] GO:0032482 [Rab protein signal transduction] GO:0032580 [Golgi cisterna membrane] GO:0043005 [neuron projection] GO:0048260 [positive regulation of receptor-mediated endocytosis] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0070062 [extracellular exosome] GO:0098559 [cytoplasmic side of early endosome membrane] GO:2000643 [positive regulation of early endosome to late endosome transport] Show all	225 aa 24.3 kDa	No	0