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RAB21

GENERAL INFORMATION

Gene name

 RAB21

Gene description

 RAB21, member RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA016988 , CAB037048
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RAB21 (HGNC Symbol)

Synonyms

 KIAA0118

Description

 RAB21, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

Chromosome

 12

Cytoband

 q21.1

Chromosome location (bp)

 71754874 - 71800285

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080371 (version 83.38)

Entrez gene

 23011

UniProt

 Q9UL25 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL25

Antibodypedia

 RAB21 antibodies

PROTEIN BROWSER
RAB21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB21-001
ENSP00000261263
ENST00000261263
Q9UL25 [Direct mapping]
Ras-related protein Rab-21
A0A024RBA9 [Target identity:100%; Query identity:100%]
RAB21, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005802 [trans-Golgi network]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008089 [anterograde axon cargo transport]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0012506 [vesicle membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017157 [regulation of exocytosis]
GO:0019003 [GDP binding]
GO:0030516 [regulation of axon extension]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0032482 [Rab protein signal transduction]
GO:0032580 [Golgi cisterna membrane]
GO:0043005 [neuron projection]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0070062 [extracellular exosome]
GO:0098559 [cytoplasmic side of early endosome membrane]
GO:2000643 [positive regulation of early endosome to late endosome transport]
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 225 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.