Expression of CPB2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Carboxypeptidase B2 (plasma)

Protein class

Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004146

GENE INFORMATION
Gene name	CPB2 (HGNC Symbol)
Synonyms	CPU, PCPB, TAFI
Description	Carboxypeptidase B2 (plasma) (HGNC Symbol)
Entrez gene summary	Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	13
Cytoband	q14.13
Chromosome location (bp)	46053186 - 46105076
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080618 (version 83.38)
Entrez gene	1361
UniProt	Q96IY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IY4
Antibodypedia	CPB2 antibodies

PROTEIN BROWSER

CPB2-001	CPB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPB2-001 ENSP00000181383 ENST00000181383	Q96IY4 [Direct mapping] Carboxypeptidase B2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003331 [positive regulation of extracellular matrix constituent secretion] GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0009408 [response to heat] GO:0010757 [negative regulation of plasminogen activation] GO:0042493 [response to drug] GO:0042730 [fibrinolysis] GO:0051918 [negative regulation of fibrinolysis] GO:0070062 [extracellular exosome] GO:0071333 [cellular response to glucose stimulus] GO:0097421 [liver regeneration] GO:2000346 [negative regulation of hepatocyte proliferation] Show all	423 aa 48.4 kDa	Yes	0
CPB2-201 ENSP00000400714 ENST00000439329	A0A087WSY5 [Direct mapping] Carboxypeptidase B2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	386 aa 44 kDa	Yes	0