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CPB2

GENERAL INFORMATION

Gene name

 CPB2

Gene description

 Carboxypeptidase B2 (plasma)

Protein class

 Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA004146
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 CPB2 (HGNC Symbol)

Synonyms

 CPU, PCPB, TAFI

Description

 Carboxypeptidase B2 (plasma) (HGNC Symbol)

Entrez gene summary

 Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

 13

Cytoband

 q14.13

Chromosome location (bp)

 46053186 - 46105076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080618 (version 83.38)

Entrez gene

 1361

UniProt

 Q96IY4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IY4

Antibodypedia

 CPB2 antibodies

PROTEIN BROWSER
CPB2-001
CPB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPB2-001
ENSP00000181383
ENST00000181383
Q96IY4 [Direct mapping]
Carboxypeptidase B2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003331 [positive regulation of extracellular matrix constituent secretion]
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0009408 [response to heat]
GO:0010757 [negative regulation of plasminogen activation]
GO:0042493 [response to drug]
GO:0042730 [fibrinolysis]
GO:0051918 [negative regulation of fibrinolysis]
GO:0070062 [extracellular exosome]
GO:0071333 [cellular response to glucose stimulus]
GO:0097421 [liver regeneration]
GO:2000346 [negative regulation of hepatocyte proliferation]
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 423 aa
48.4 kDa 		Yes 0
CPB2-201
ENSP00000400714
ENST00000439329
A0A087WSY5 [Direct mapping]
Carboxypeptidase B2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 386 aa
44 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.