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Distinct granular cytoplasmic positivity was found in most prostate cancers and in few liver cancers. Remaining malignant tissues were in general negative.
Strong cytoplasmic immunoreactivity was observed in prostate cancers and several cases of cervical, renal, colorectal and lung cancers. Thyroid cancers along with cases of malignant gliomas, melanomas, endometrial, urothelial and testicular cancer displayed moderate to strong immunoreactivity.
GENE INFORMATION
Gene name
ARG2
Synonyms
Description
Arginase 2 (HGNC Symbol)
Entrez gene summary
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
