Cell atlas - IL12RB2 - The Human Protein Atlas

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IL12RB2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	IL12RB2
Gene description	Interleukin 12 receptor, beta 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Group enriched (SK-MEL-30, SCLC-21H, THP-1, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA024168
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SK-MEL-30, SCLC-21H, THP-1, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024168	A-431	Plasma membrane
	HPA024168	A-431	Cytosol
	HPA024168	U-2 OS	Plasma membrane
	HPA024168	U-2 OS	Cytosol
	HPA024168	U-251 MG	Plasma membrane
	HPA024168	U-251 MG	Cytosol

GENE INFORMATION
Gene name	IL12RB2
Synonyms
Description	Interleukin 12 receptor, beta 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	67307364 - 67396900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081985 (version 83.38)
Entrez gene	3595
UniProt	Q99665 (UniProt - Evidence at protein level)
neXtProt	NX_Q99665
Antibodypedia	IL12RB2 antibodies

PROTEIN BROWSER

IL12RB2-001	IL12RB2-002	IL12RB2-004	IL12RB2-201	IL12RB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL12RB2-001 ENSP00000262345 ENST00000262345	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0032496 [response to lipopolysaccharide] GO:0032609 [interferon-gamma production] GO:0032729 [positive regulation of interferon-gamma production] GO:0034097 [response to cytokine] Show all	862 aa 97.1 kDa	Yes	1
IL12RB2-002 ENSP00000400959 ENST00000441640	H0Y5V0 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	230 aa 26.8 kDa	No	0
IL12RB2-004 ENSP00000360039 ENST00000371000	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	659 aa 74.6 kDa	Yes	1
IL12RB2-201 ENSP00000445276 ENST00000541374	A0A0A0MTN7 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	635 aa 71.7 kDa	Yes	0
IL12RB2-202 ENSP00000442443 ENST00000544434	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	776 aa 87.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.