Tissue expression of IL12RB2 - Summary - The Human Protein Atlas

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IL12RB2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IL12RB2
Gene description	Interleukin 12 receptor, beta 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (pancreas)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA024168
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas)

GENE INFORMATION
Gene name	IL12RB2
Synonyms
Description	Interleukin 12 receptor, beta 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	67307364 - 67396900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081985 (version 83.38)
Entrez gene	3595
UniProt	Q99665 (UniProt - Evidence at protein level)
neXtProt	NX_Q99665
Antibodypedia	IL12RB2 antibodies

PROTEIN BROWSER

IL12RB2-001	IL12RB2-002	IL12RB2-004	IL12RB2-201	IL12RB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL12RB2-001 ENSP00000262345 ENST00000262345	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0032496 [response to lipopolysaccharide] GO:0032609 [interferon-gamma production] GO:0032729 [positive regulation of interferon-gamma production] GO:0034097 [response to cytokine] Show all	862 aa 97.1 kDa	Yes	1
IL12RB2-002 ENSP00000400959 ENST00000441640	H0Y5V0 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	230 aa 26.8 kDa	No	0
IL12RB2-004 ENSP00000360039 ENST00000371000	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	659 aa 74.6 kDa	Yes	1
IL12RB2-201 ENSP00000445276 ENST00000541374	A0A0A0MTN7 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	635 aa 71.7 kDa	Yes	0
IL12RB2-202 ENSP00000442443 ENST00000544434	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	776 aa 87.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.