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KAT6A

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GENERAL INFORMATION

Gene name

 KAT6A

Gene description

 K(lysine) acetyltransferase 6A

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the nucleoli & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

Additional location

 In addition localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
CAB017023 , HPA065052
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the nucleoli & cytosol.

Main location

 Nuclear speckles (approved)

Additional location

 Nucleoli (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017023 U-2 OS No staining    
CAB017023 U-251 MG Nuclear speckles
HPA065052 RH-30 Nucleoli
Nuclear speckles
Cytosol
HPA065052 U-2 OS Nuclear speckles
Cytosol

GENE INFORMATION

Gene name

 KAT6A (HGNC Symbol)

Synonyms

 MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220

Description

 K(lysine) acetyltransferase 6A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 41929479 - 42051990

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083168 (version 83.38)

Entrez gene

 7994

UniProt

 Q92794 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92794

Antibodypedia

 KAT6A antibodies

PROTEIN BROWSER
KAT6A-001
KAT6A-002
KAT6A-003
KAT6A-004
KAT6A-005
KAT6A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KAT6A-001
ENSP00000265713
ENST00000265713
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
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 2004 aa
225 kDa 		No 0
KAT6A-002
ENSP00000430606
ENST00000485568
A5PLL3 [Direct mapping]
Histone acetyltransferase
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0048513 [organ development]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 815 aa
93.2 kDa 		No 0
KAT6A-003
ENSP00000399638
ENST00000418721
C9K0F9 [Direct mapping]
Histone acetyltransferase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0048513 [organ development]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 728 aa
84.1 kDa 		No 0
KAT6A-004
ENSP00000385888
ENST00000406337
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
Show all
 2004 aa
225 kDa 		No 0
KAT6A-005
ENSP00000396699
ENST00000426524
C9JJY6 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 13 aa
1.6 kDa 		No 0
KAT6A-201
ENSP00000380136
ENST00000396930
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003007 [heart morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0035162 [embryonic hemopoiesis]
GO:0035909 [aorta morphogenesis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060325 [face morphogenesis]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
Show all
 2004 aa
225 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.