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Most colorectal, lung, gastric, urothelial, cervical and skin cancers as well as several cases of gliomas, breast, ovarian, pancreatic and liver cancers showed moderate to strong cytoplasmic and/or nuclear staining. Most of the remaining cancers were negative.
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]
Q6ISB3 [Direct mapping] Grainyhead-like protein 2 homolog
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Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0001843 [neural tube closure] GO:0003208 [cardiac ventricle morphogenesis] GO:0003382 [epithelial cell morphogenesis] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005911 [cell-cell junction] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007155 [cell adhesion] GO:0007420 [brain development] GO:0008283 [cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0016020 [membrane] GO:0021915 [neural tube development] GO:0030323 [respiratory tube development] GO:0031490 [chromatin DNA binding] GO:0034329 [cell junction assembly] GO:0035264 [multicellular organism growth] GO:0042733 [embryonic digit morphogenesis] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0044030 [regulation of DNA methylation] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048568 [embryonic organ development] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0051973 [positive regulation of telomerase activity] GO:0060324 [face development] GO:0060463 [lung lobe morphogenesis] GO:0060487 [lung epithelial cell differentiation] GO:0060672 [epithelial cell morphogenesis involved in placental branching] GO:0070830 [bicellular tight junction assembly] GO:0090132 [epithelium migration]