Fields »
ABOUT
HELP
BLOG
TNPO1

GENERAL INFORMATION

Gene name

 TNPO1

Gene description

 Transportin 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB016325
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TNPO1 (HGNC Symbol)

Synonyms

 IPO2, KPNB2, MIP, MIP1, TRN

Description

 Transportin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 72816312 - 72916733

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083312 (version 83.38)

Entrez gene

 3842

UniProt

 Q92973 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92973

Antibodypedia

 TNPO1 antibodies

PROTEIN BROWSER
TNPO1-001
TNPO1-006
TNPO1-013
TNPO1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNPO1-001
ENSP00000336712
ENST00000337273
Q92973 [Direct mapping]
Transportin-1
A0A024RAM0 [Target identity:100%; Query identity:100%]
Transportin 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 898 aa
102.4 kDa 		No 0
TNPO1-006
ENSP00000425118
ENST00000506351
Q92973 [Direct mapping]
Transportin-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 890 aa
101.3 kDa 		No 0
TNPO1-013
ENSP00000428899
ENST00000523768
Q92973 [Direct mapping]
Transportin-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006996 [organelle organization]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 848 aa
96.9 kDa 		No 0
TNPO1-014
ENSP00000474059
ENST00000605210
S4R398 [Direct mapping]
Transportin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 193 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.