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Cancer tissues showed moderate to strong nuclear staining. Carcinoid and several cases of liver cancers were negative.
GENE INFORMATION
Gene name
REST (HGNC Symbol)
Synonyms
NRSF, XBR
Description
RE1-silencing transcription factor (HGNC Symbol)
Entrez gene summary
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010629 [negative regulation of gene expression] GO:0015271 [outward rectifier potassium channel activity] GO:0017053 [transcriptional repressor complex] GO:0032348 [negative regulation of aldosterone biosynthetic process] GO:0032403 [protein complex binding] GO:0035690 [cellular response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043922 [negative regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045955 [negative regulation of calcium ion-dependent exocytosis] GO:0046676 [negative regulation of insulin secretion] GO:0046872 [metal ion binding] GO:0050768 [negative regulation of neurogenesis] GO:0060379 [cardiac muscle cell myoblast differentiation] GO:0070933 [histone H4 deacetylation] GO:0071257 [cellular response to electrical stimulus] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071805 [potassium ion transmembrane transport] GO:2000065 [negative regulation of cortisol biosynthetic process] GO:2000706 [negative regulation of dense core granule biogenesis] GO:2000740 [negative regulation of mesenchymal stem cell differentiation] GO:2000798 [negative regulation of amniotic stem cell differentiation]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010629 [negative regulation of gene expression] GO:0015271 [outward rectifier potassium channel activity] GO:0017053 [transcriptional repressor complex] GO:0032348 [negative regulation of aldosterone biosynthetic process] GO:0035690 [cellular response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043922 [negative regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045955 [negative regulation of calcium ion-dependent exocytosis] GO:0046676 [negative regulation of insulin secretion] GO:0046872 [metal ion binding] GO:0050768 [negative regulation of neurogenesis] GO:0060379 [cardiac muscle cell myoblast differentiation] GO:0070933 [histone H4 deacetylation] GO:0071257 [cellular response to electrical stimulus] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071805 [potassium ion transmembrane transport] GO:2000065 [negative regulation of cortisol biosynthetic process] GO:2000706 [negative regulation of dense core granule biogenesis] GO:2000740 [negative regulation of mesenchymal stem cell differentiation] GO:2000798 [negative regulation of amniotic stem cell differentiation]
