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REST

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GENERAL INFORMATION

Gene name

 REST

Gene description

 RE1-silencing transcription factor

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA006079
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006079 A-431 Nucleoplasm
Cytosol
HPA006079 U-2 OS Nucleoplasm
Cytosol
HPA006079 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 REST (HGNC Symbol)

Synonyms

 NRSF, XBR

Description

 RE1-silencing transcription factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 56907876 - 56935844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084093 (version 83.38)

Entrez gene

 5978

UniProt

 Q13127 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13127

Antibodypedia

 REST antibodies

PROTEIN BROWSER
REST-001
REST-201
REST-202
REST-203
REST-204
REST-205

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REST-001
ENSP00000311816
ENST00000309042
Q13127 [Direct mapping]
RE1-silencing transcription factor
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0015271 [outward rectifier potassium channel activity]
GO:0017053 [transcriptional repressor complex]
GO:0032348 [negative regulation of aldosterone biosynthetic process]
GO:0032403 [protein complex binding]
GO:0035690 [cellular response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045955 [negative regulation of calcium ion-dependent exocytosis]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0050768 [negative regulation of neurogenesis]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0070933 [histone H4 deacetylation]
GO:0071257 [cellular response to electrical stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:2000065 [negative regulation of cortisol biosynthetic process]
GO:2000706 [negative regulation of dense core granule biogenesis]
GO:2000740 [negative regulation of mesenchymal stem cell differentiation]
GO:2000798 [negative regulation of amniotic stem cell differentiation]
Show all
 1097 aa
121.9 kDa 		No 0
REST-201
ENSP00000479151
ENST00000611211
A0A087X1C2 [Direct mapping]
RE1-silencing transcription factor; RE1-silencing transcription factor, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 340 aa
38.2 kDa 		No 0
REST-202
ENSP00000484206
ENST00000612429
L0B3Z2 [Direct mapping]
RE1-silencing transcription factor; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 342 aa
38.5 kDa 		No 0
REST-203
ENSP00000484058
ENST00000616975
A0A087X1C2 [Direct mapping]
RE1-silencing transcription factor; RE1-silencing transcription factor, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 340 aa
38.2 kDa 		No 0
REST-204
ENSP00000484836
ENST00000619101
Q13127 [Direct mapping]
RE1-silencing transcription factor
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0015271 [outward rectifier potassium channel activity]
GO:0017053 [transcriptional repressor complex]
GO:0032348 [negative regulation of aldosterone biosynthetic process]
GO:0035690 [cellular response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045955 [negative regulation of calcium ion-dependent exocytosis]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0050768 [negative regulation of neurogenesis]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0070933 [histone H4 deacetylation]
GO:0071257 [cellular response to electrical stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:2000065 [negative regulation of cortisol biosynthetic process]
GO:2000706 [negative regulation of dense core granule biogenesis]
GO:2000740 [negative regulation of mesenchymal stem cell differentiation]
GO:2000798 [negative regulation of amniotic stem cell differentiation]
Show all
 1097 aa
121.9 kDa 		No 0
REST-205
ENSP00000481650
ENST00000622863
L0B1S6 [Direct mapping]
RE1-silencing transcription factor; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043065 [positive regulation of apoptotic process]
GO:0045665 [negative regulation of neuron differentiation]
GO:0046872 [metal ion binding]
Show all
 314 aa
34.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.