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WBP11

GENERAL INFORMATION

Gene name

 WBP11

Gene description

 WW domain binding protein 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA040037 , HPA046403 , HPA049126
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 WBP11 (HGNC Symbol)

Synonyms

 NPWBP, PPP1R165, SIPP1

Description

 WW domain binding protein 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 14784579 - 14803540

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084463 (version 83.38)

Entrez gene

 51729

UniProt

 Q9Y2W2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2W2

Antibodypedia

 WBP11 antibodies

PROTEIN BROWSER
WBP11-001
WBP11-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WBP11-001
ENSP00000261167
ENST00000261167
Q9Y2W2 [Direct mapping]
WW domain-binding protein 11
A0A024RAW9 [Target identity:100%; Query identity:100%]
WW domain binding protein 11, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0050699 [WW domain binding]
GO:0050790 [regulation of catalytic activity]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 641 aa
70 kDa 		No 0
WBP11-005
ENSP00000440988
ENST00000535328
F5GXS9 [Direct mapping]
WW domain-binding protein 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006396 [RNA processing]
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 53 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.