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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

Score

Score

Antibodies

Column

 
 
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APOB
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

APOB

Gene description

Apolipoprotein B

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (liver, small intestine, duodenum)
GTEx:Group enriched (liver, small intestine)
FANTOM5:Group enriched (liver, small intestine, colon)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 2 antibodies.
HPA049793 , CAB016070
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, colon)

GENE INFORMATION

Gene name

APOB

Synonyms

Description

Apolipoprotein B (HGNC Symbol)

Entrez gene summary

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p24.1

Chromosome location (bp)

21001429 - 21044073

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084674 (version 83.38)

Entrez gene

338

UniProt

P04114 (UniProt - Evidence at protein level)

neXtProt

NX_P04114

Antibodypedia

APOB antibodies

PROTEIN BROWSER

APOB-001
APOB-002
APOB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOB-001
ENSP00000233242
ENST00000233242
P04114 [Direct mapping]
Apolipoprotein B-100 Apolipoprotein B-48
Show all
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001701 [in utero embryonic development]
GO:0005319 [lipid transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006642 [triglyceride mobilization]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008201 [heparin binding]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0009566 [fertilization]
GO:0009615 [response to virus]
GO:0009743 [response to carbohydrate]
GO:0009791 [post-embryonic development]
GO:0010008 [endosome membrane]
GO:0010033 [response to organic substance]
GO:0010269 [response to selenium ion]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0010886 [positive regulation of cholesterol storage]
GO:0012506 [vesicle membrane]
GO:0015629 [actin cytoskeleton]
GO:0016042 [lipid catabolic process]
GO:0017127 [cholesterol transporter activity]
GO:0019433 [triglyceride catabolic process]
GO:0030301 [cholesterol transport]
GO:0030317 [sperm motility]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031904 [endosome lumen]
GO:0031983 [vesicle lumen]
GO:0032496 [response to lipopolysaccharide]
GO:0033344 [cholesterol efflux]
GO:0034359 [mature chylomicron]
GO:0034360 [chylomicron remnant]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0034363 [intermediate-density lipoprotein particle]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0035473 [lipase binding]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042159 [lipoprotein catabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042953 [lipoprotein transport]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045540 [regulation of cholesterol biosynthetic process]
GO:0048844 [artery morphogenesis]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071379 [cellular response to prostaglandin stimulus]
GO:0071682 [endocytic vesicle lumen]
Show all
4563 aa
515.5 kDa
Yes 0
APOB-002
ENSP00000382200
ENST00000399256
A8MUN2 [Direct mapping]
Apolipoprotein B-100
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0015629 [actin cytoskeleton]
Show all
828 aa
92.6 kDa
Yes 0
APOB-201
ENSP00000477990
ENST00000616098
A0A087WTM7 [Direct mapping]
Apolipoprotein B-100
Show all
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0006869 [lipid transport]
Show all
4344 aa
489.8 kDa
Yes 0

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The Human Protein Atlas project is funded
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