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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RAB10
  • TISSUE

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  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

RAB10, member RAS oncogene family

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA045611

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic immunoreactivity was observed in most malignant cells. Low grade urothelial carcinomas were strongly stained. Testicular cancers were generally negative.

GENE INFORMATION

Gene name

RAB10

Synonyms

Description

RAB10, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

26034107 - 26137454

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084733 (version 83.38)

Entrez gene

10890

UniProt

P61026 (UniProt - Evidence at protein level)

neXtProt

NX_P61026

Antibodypedia

RAB10 antibodies

PROTEIN BROWSER

RAB10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAB10-001
ENSP00000264710
ENST00000264710
P61026 [Direct mapping]
Ras-related protein Rab-10
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0009306 [protein secretion]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0017157 [regulation of exocytosis]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030859 [polarized epithelial cell differentiation]
GO:0031489 [myosin V binding]
GO:0032482 [Rab protein signal transduction]
GO:0032593 [insulin-responsive compartment]
GO:0032869 [cellular response to insulin stimulus]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045200 [establishment of neuroblast polarity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0061024 [membrane organization]
GO:0061467 [basolateral protein localization]
GO:0070062 [extracellular exosome]
GO:0071236 [cellular response to antibiotic]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:0072372 [primary cilium]
GO:0072659 [protein localization to plasma membrane]
GO:0090150 [establishment of protein localization to membrane]
GO:0097051 [establishment of protein localization to endoplasmic reticulum membrane]
Show all
200 aa
22.5 kDa
No 0

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