Expression of WDFY1 in cancer - Summary

CANCER ATLAS

Gene description

WD repeat and FYVE domain containing 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050603

GENE INFORMATION
Gene name	WDFY1 (HGNC Symbol)
Synonyms	FENS-1, KIAA1435, WDF1, ZFYVE17
Description	WD repeat and FYVE domain containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	223855716 - 223945387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085449 (version 83.38)
Entrez gene	57590
UniProt	Q8IWB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWB7
Antibodypedia	WDFY1 antibodies

PROTEIN BROWSER

WDFY1-001	WDFY1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDFY1-001 ENSP00000233055 ENST00000233055	Q8IWB7 [Direct mapping] WD repeat and FYVE domain-containing protein 1 A0A024R488 [Target identity:100%; Query identity:100%] WD repeat and FYVE domain containing 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005634 [nucleus] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0046872 [metal ion binding] Show all	410 aa 46.3 kDa	No	0
WDFY1-005 ENSP00000395416 ENST00000429915	C9JJ54 [Direct mapping] WD repeat and FYVE domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	215 aa 24.3 kDa	No	0