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WDFY1

GENERAL INFORMATION

Gene name

 WDFY1

Gene description

 WD repeat and FYVE domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050603
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 WDFY1 (HGNC Symbol)

Synonyms

 FENS-1, KIAA1435, WDF1, ZFYVE17

Description

 WD repeat and FYVE domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 223855716 - 223945387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085449 (version 83.38)

Entrez gene

 57590

UniProt

 Q8IWB7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWB7

Antibodypedia

 WDFY1 antibodies

PROTEIN BROWSER
WDFY1-001
WDFY1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDFY1-001
ENSP00000233055
ENST00000233055
Q8IWB7 [Direct mapping]
WD repeat and FYVE domain-containing protein 1
A0A024R488 [Target identity:100%; Query identity:100%]
WD repeat and FYVE domain containing 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0046872 [metal ion binding]
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 410 aa
46.3 kDa 		No 0
WDFY1-005
ENSP00000395416
ENST00000429915
C9JJ54 [Direct mapping]
WD repeat and FYVE domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 215 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.