Expression of MTIF2 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial translational initiation factor 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006021

GENE INFORMATION
Gene name	MTIF2 (HGNC Symbol)
Synonyms	IF-2mt
Description	Mitochondrial translational initiation factor 2 (HGNC Symbol)
Entrez gene summary	During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.1
Chromosome location (bp)	55236595 - 55269347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085760 (version 83.38)
Entrez gene	4528
UniProt	P46199 (UniProt - Evidence at protein level)
neXtProt	NX_P46199
Antibodypedia	MTIF2 antibodies

PROTEIN BROWSER

MTIF2-001	MTIF2-002	MTIF2-005	MTIF2-007	MTIF2-008	MTIF2-009	MTIF2-010	MTIF2-011	MTIF2-012	MTIF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTIF2-001 ENSP00000263629 ENST00000263629	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0
MTIF2-002 ENSP00000384481 ENST00000403721	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0
MTIF2-005 ENSP00000393337 ENST00000366137	E7EW07 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.6 kDa	No	0
MTIF2-007 ENSP00000388640 ENST00000441307	A0A0E3D6N0 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.5 kDa	No	0
MTIF2-008 ENSP00000416057 ENST00000420637	C9JIY5 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3.2 kDa	No	0
MTIF2-009 ENSP00000383880 ENST00000404297	B5MCU1 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8.4 kDa	No	0
MTIF2-010 ENSP00000403492 ENST00000418823	H7C213 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		301 aa 33.5 kDa	No	0
MTIF2-011 ENSP00000393025 ENST00000412530		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.9 kDa	No	0
MTIF2-012 ENSP00000399531 ENST00000417363		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
MTIF2-201 ENSP00000378099 ENST00000394600	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0